Primary engineering controls (PECs) are fundamental to most compounding operations. Biological safety cabinets (BSCs) are increasingly popular. In fact, BSC adoption rates have reached 84% in facilities with 200+ beds. PECs are also well rated by their users. CAIs/CACIs receive 98% satisfaction ratings and are increasingly likely to be located within the cleanroom. Notably, there was no expansion this year for pharmaceutical manufacturing grade isolators, which feature built-in, automated decontamination systems.
Pharmacy directors rely on a wide array of PECs to support compounding operations: 83% use LAFWs, 74% use BSCs, and 28% take advantage of isolators.
Class II, Type A2 BSCs remain the most commonly used, followed by Class II, Type B2 BSCs.
Historically, CAIs and CACIs were most commonly utilized in the segregated compounding area. As more facilities comply with USP <800>, isolators are moving into the cleanroom.
Pharmaceutical manufacturing grade isolators feature a built-in, automated decontamination system, yet this advanced technology has not experienced widespread adoption in hospital pharmacies. Looking ahead, just 4% of facilities are planning to purchase this technology over the next 5 years.