Equashield II is a closed drug transfer system that helps protect health care professionals from hazardous drug and vapor exposure. The system has a quick deployment time, and covers more routes of exposure to provide protection to personnel preparing and administering hazardous drugs. Equashield II has been clinically proven to eliminate surface contamination with antineoplastic agents and prevent microbial ingress. The system includes a syringe with a fully encapsulated barrel and plunger, built-in closed pressure equalization, and an integrated single motion connector that remains free of drug residuals after multiple connections.